Babies
The project database currently holds 45 relevant grants.
- Adrenal disease in newborn babies
- Birth difficulties - a follow-up study in children
- Studying how the brain responds to injury early in life and identifying any visual, movement or co-ordination problems which may result.
- Bowel obstruction in newborn babies
- Brain cooling to avoid damage in newborn babies
- Developing new methods to identify babies who could benefit from cooling treatment which may reduce or prevent brain damage in newborn babies.
- Brittle bone disease
- An inherited "brittle bone" disease can cause recurrent fractures, retarded growth and skeletal deformity in children. The long term aim is to develop a treatment for the bone abnormalities which can be given to affected babies whilst still in the womb.
- Bronchiolitis
- Investigating the response of the immune system to this serious lung infection in babies, which may lead to effective treatments for infants with bronchiolitis.
- Bronchiolitis
- Investigating the body’s response to this serious lung infection in babies, which may lead to the development of a vaccine.
- Bronchiolitis and RSV infection
- Studying proteins found in the blood of healthy infants and infants infected with respiratory syncytial virus, with the aim of improving diagnosis and treatment in babies with illnesses such as bronchiolitis.
- Cerebral Palsy
- Investigating whether stem cells can be transplanted into the brain to replace damaged brain tissue and prevent cerebral palsy.
- Cerebral palsy - a possible new treatment
- Investigating the development of the brain which may lead to new treatments to reduce the number of children suffering from cerebral palsy.
- Cleft lip and palate — baby plates
- Examining whether ”baby plates” which are fitted inside the mouth, help feeding and speech development in children with cleft lip and/or palate.
- Computer technology to find genes that cause malformations
- The development of an Internet based tool to help identify genes involved in causing birth defects
- Ectodermal dysplasias affecting the skin, hair, teeth and nails
- Searching for the gene abnormalities which lead to poor development of these tissues.
- Epilepsy, Episodic Ataxia and faulty genes
- To study molecular genetic and cellular expression studies of the calcium channel CACNA1A in human epilepsy.
- Eye disease in preterm babies
- Investigating how fluctuating oxygen levels affect normal eye development which may ultimately prevent some cases of blindness.
- Fetal growth restriction and placental blood flow
- Genetics of oral-facial-digital syndromes and kidney disease
- Investigating the function of the gene responsible for this potentially life-threatening disorder, improving our understanding of the condition.
- Gut failure in children
- Investigating the causes of microvillus atrophy where there is a failure of absorption of all nutrients and death is inevitable unless intravenous feeding is commenced
- Heart rate sensor for newborns
- Developing an electronic ‘hands-free’ device to measure a newborn baby’s heart rate during resuscitation
- Hirschsprung’s Disease
- Studying a possible new treatment for Hirschprung’s disease which causes life-threatening bowel obstruction in babies due to a lack of nerve cells in the rectum.
- Hydrocephalus (water on the brain)
- Developing methods which may reduce the need for surgery in patients with hydrocephalus where there is an abnormal accumulation of fluid on the brain.
- Hydrocephalus and brain haemorrhage in premature babies
- Researching methods to prevent or minimise the extent of damage caused by hydrocephalus and brain haemorrhage in premature babies.
- Hydrocephalus — identifying new treatments
- Infection and meningitis in newborn babies
- Identifying babies at risk of becoming infected so that preventative treatment can be given.
- Infection by invasive candidiasis
- Development of novel diagnostic tests for invasive candidiasis, a life threatening infection caused by a yeast-like fungus called Candida.
- Infection in premature babies
- Investigating whether infection in premature babies can be reduced by treatment with a substance which helps the white blood cells to fight infection.
- Meningitis - a possible new treatment
- Understanding more about our natural defence against a meningitis-causing bacterium.
- Metabolic diseases - new methods of treatment
- Developing a test to evaluate the effectiveness of new drugs used to treat metabolic diseases (where chemicals accumulate to toxic levels within the body causing widespread problems which can be life threatening).
- Neurofibromatosis type 1
- Investigating the function of the gene affected in this relatively common genetic disease which causes significant abnormalities including learning difficulties, tumours of the central nervous system and skeletal deformities in children.
- Nutrition for babies after surgery
- Investigating ways of enhancing recovery and reducing infection in babies that are fed by a drip following bowel operations.
- Pain prevention in young infants
- Investigating the increase in nerve density and skin sensitivity which may result from tissue damage and cause long-term pain in infants.
- Premature babies — the effects of oxygen fluctuations
- Aiming to improve the intensive care of premature babies by investigating the effects of oxygen levels on the development of the brain.
- Premature babies treated with steroids - a follow-up study
- Studying the long-term effects of steroids used to treat chronic lung disease in premature babies.
- Premature babies preventing hydrocephalus and cerebral palsy
- Developing a new treatment which may prevent complications of premature birth by blocking the effects of a chemical which produces scarring around the brain.
- Premature baby care — when is it best to start milk feeds?
- Evaluating the relative benefits and risks of starting milk feeds early or late for premature babies which should lead to an improvement in the care of these vulnerable infants.
- Preterm babies treated with steroids - a follow-up study in teenagers
- Investigating the long-term effects of steroid use on lung function, growth and intellectual outcome in preterm babies.
- Preterm infants - preventing brain damage
- Investigating the relationship between infection and brain damage with the aim of identifying those babies most at risk.
- Retinopathy of prematurity - preventing childhood blindness
- Exploring innovative methods that could be used to screen at-risk babies worldwide for retinopathy of prematurity, so that treatment can be given and blindness prevented.
- Sickle cell disease - preventing complications
- Looking at the causes and prevention of sickle cell ‘crises’ which can cause excruciating pain, stroke, bone, renal and lung disease.
- Sickle cell disease - studying blood vessels
- Improving our understanding of sickle cell disease by studying the regulation of blood vessels in patients with this condition.
- Skin itching
- Skull growth
- Understanding more about the mechanisms of skull growth with the aim of improving the treatment of genetic conditions where the skull stops growing prematurely.
- Spinal development
- Aiming to identify the genetic causes of abnormal spinal development.
- Ultrasound measurement of bone density in newborn babies
- Ultrasound measurement of bone density in newborn babies
- Understanding brain damage in newborn babies
- Understanding brain damage in newborn babies
