Preterm infants - preventing brain damage

Location: Department of Maternal and Fetal Medicine, Queen Charlotte’s and Chelsea Hospital Campus and the Department of Paediatrics, ICSM, Hammersmith Campus, London.
Amount: £170,606
Status: Research completed
Start Date: 6th September 1999
Finish Date: 31st January 2004
Grantholder: Dr M H F Sullivan, PhD, Dr M A Rutherford MD, MRCPCH, Professor A D Edwards, FRCP
Research worker: Dr J Steel and Dr N Kinnea

Babies born prematurely are particularly vulnerable to brain damage, and prematurity is a major cause of cerebral palsy and long-term disability in children. As the number of very premature infants who survive increases, so the number of children with disability is also getting larger.

It is now clear that infection is a major risk factor for prematurity: and whilst the cause of perinatal brain damage is probably multifactorial, this project will investigate whether such infection is related to this damage. If so, it should then be possible to identify the babies most at risk very soon after delivery and also to develop appropriate treatments for them.

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