severe skin disease

Skin is the largest human organ with massive responsibilities: regulating temperature and fluid loss and protecting against infection. It is only when something goes wrong with it that you understand its significance. Harlequin ichthyosis is an extremely severe skin disorder that affects babies, who are born with a thick, hard shell covering their bodies. Diamond-shaped plates are separated by deep cracks, which invite infection, and the thick, tight skin on the chest can restrict breathing.