Bowel obstruction in newborn babies | Children's Charity

Bowel obstruction in newborn babies

This research was completed on 20 October 2006

Project LeaderDr F Capon PhD, Dr E M K Chung MD, FRCPCH
LocationDepartment of Paediatrics and Child Health, University College London
Grant awarded7 July 2005
Start date21 January 2005
End date20 October 2006
Grant amount£36,699.00
Grant codeSP4062

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These researchers are investigating the most common form of inherited bowel obstruction affecting babies. The condition is called infantile hypertrophic pyloric stenosis (IHPS) and it affects almost one thousand newborn babies each year in the UK. Feeding leads to overgrowth (hypertrophy) of muscle in the wall of the stomach outlet (pylorus) causing blockage (stenosis) with severe vomiting and dehydration. The condition was fatal before the introduction of surgical treatment in 1911. Effective treatment now involves hospital admission for fluid rehydration, anaesthesia, and an operation to cut the overgrown muscle but complications and even deaths still occur. IHPS runs in families and is usually caused by the combined effects of several faulty genes. This research aims to identify the faulty genes involved. This should greatly increase our understanding of the condition and lead to new methods of diagnosis. Early detection and a better understanding of the condition could then allow development of alternatives to surgical treatment.

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