Cleft lip and palate - identifying the genes
This research was completed on 31 January 2003
|Project Leader||Professor R M Winter, FRCP and Dr M Mars, PhD, FDS.|
|Location||Molecular Genetics Unit and the Clinical Genetics and Fetal Medicine Unit at the Institute of Child Health in conjunction with the Maxillofacial and Dental Department, Hospital for Sick Children, London.|
|Grant awarded||8 July 1999|
|Start date||1 February 2000|
|End date||31 January 2003|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.Cleft lip, with or without cleft palate, is one of the most common birth malformations. Children with these disorders may require multiple operations and a variety of treatments including speech therapy and orthodontics. As this condition is about thirty times more likely to occur in the brother or sister of an affected individual than in the general population, there is thought to be a genetic component to the problem. These researchers have contacted families in which several members have a cleft lip and they will now attempt to identify those genes which are shared by affected family members. By gathering this information, vital clues to the causes of cleft lip and palate could be unveiled, bringing the prevention of this distressing disorder a step closer.