Diabetic wound healing
This research was completed on 31 October 2009
|Project Leader||Dr D Becker, PhD|
|Location||Department of Anatomy and Developmental Biology, University College London|
|Grant awarded||6 July 2006|
|Start date||1 November 2006|
|End date||31 October 2009|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.
The number of people diagnosed with diabetes in the UK passed the 2 million mark in 2005. Estimates suggest that this figure will continue to rise affecting the lives of increasing numbers of individuals and putting an ever increasing load on the NHS. Many complications can occur due to diabetes such as heart disease, strokes, kidney disease and blindness. However, the most common reason for hospital admission is due to diabetic foot ulcers which are notoriously slow to heal. These ulcers cause the patient great pain and if not treated effectively can lead to limb amputation. These researchers have found that the way cells communicate is crucial to the wound healing process. The team has shown that they can modify cell to cell communication at a wound site by applying a bioactive gel which speeds up wound healing and reduces scar formation. Cells can communicate with one another directly through intercellular channels and recent work indicates that cell to cell communication in a diabetic wound is abnormal and is likely to contribute to slow healing. The project aims to confirm the reason for slow healing in diabetics and investigate the ability of the bioactive gel to speed up the process. If successful, this project would provide the first effective treatment for long term wounds such as diabetic foot ulcers.