Guillain-Barré syndrome | Children's Charity

Guillain-Barré syndrome

This research was completed on 6 February 2006

Project LeaderProfessor Richard A C Hughes MD FRCP FMedSci, Professor Adrian C Hayday PhD, Professor Kenneth J Smith PhD and Dr Norman A Gregson PhD
LocationGuy's, King's and St Thomas' School of Medicine, Department of Neuroimmunology and The Peter Gorer Department of Immunobiology, Guy's Hospital, London.
Grant awarded26 October 2000
Start date18 March 2002
End date6 February 2006
Grant amount£176,139.00
Grant codeSP3661

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Guillain-Barré syndrome is the most common cause of acute neuromuscular paralysis, affecting 2000 patients each year in the United Kingdom, and leaving 20% of them dead or disabled. It is thought to be an 'autoimmune' disease, in which the body's defence mechanisms erroneously attack its own tissues ­ in this case the peripheral nerve sheaths. These researchers will further investigate their original finding that a protein covering the nerve (peripheral myelin protein 22) is the target of this autoimmune attack. Such an improvement in our understanding of the cause of Guillain-Barré syndrome should then help us design better treatment for patients.

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