Gut failure in children
This research was completed on 6 May 2005
|Project Leader||Professor P J Scambler FMedSci, Dr N Shah MSc, MRCP, Dr R J Thompson BA, BM, BCh, MRCP, MRCPCH, Professor P J Milla MSc, MB BS, FRCP, FRCPCH and Dr A D Phillips PhD.|
|Location||Molecular Medicine Unit and the Department of Gastroenterology, Institute of Child Health and the Department of Child Health, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, in conjunction with the Centre for Paediatric Gastroenterology, Royal Free Hospital, London.|
|Grant awarded||7 November 2002|
|Start date||7 May 2003|
|End date||6 May 2005|
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Microvillus atrophy is a condition that is found world-wide. It is a devastating disorder in which there is a total failure of absorption of all nutrients and death is inevitable unless intravenous feeding is commenced. The condition is inherited and starts shortly after birth with profuse watery diarrhoea. The cause is unknown and no treatments are available except liver and small bowel transplantation which has a high death rate. Identification of the cause for this condition will allow both antenatal diagnosis, possible future treatments and an insight into the normal function of the intestines.