Gut Failure in Children | Action Medical Research | Children's Charity | Children's Charity

Gut failure in children

This research was completed on 6 May 2005

Project LeaderProfessor P J Scambler FMedSci, Dr N Shah MSc, MRCP, Dr R J Thompson BA, BM, BCh, MRCP, MRCPCH, Professor P J Milla MSc, MB BS, FRCP, FRCPCH and Dr A D Phillips PhD.
LocationMolecular Medicine Unit and the Department of Gastroenterology, Institute of Child Health and the Department of Child Health, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, in conjunction with the Centre for Paediatric Gastroenterology, Royal Free Hospital, London.
Grant awarded7 November 2002
Start date7 May 2003
End date6 May 2005
Grant amount£83,541.00
Grant codeSP3825

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Microvillus atrophy is a condition that is found world-wide. It is a devastating disorder in which there is a total failure of absorption of all nutrients and death is inevitable unless intravenous feeding is commenced. The condition is inherited and starts shortly after birth with profuse watery diarrhoea. The cause is unknown and no treatments are available except liver and small bowel transplantation which has a high death rate. Identification of the cause for this condition will allow both antenatal diagnosis, possible future treatments and an insight into the normal function of the intestines.

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