Inflammation in the spine
This research was completed on 30 September 2005
|Project Leader||Professor M Benjamin, PhD and Dr D McGonagle, MRCPI.|
|Location||School of Biosciences, Cardiff University in conjunction with the Rheumatology and Rehabilitation Research Unit, University of Leeds.|
|Grant awarded||7 November 2002|
|Start date||1 December 2002|
|End date||30 September 2005|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.
The spondyloarthropathies are rheumatic disorders affecting one in a hundred of the population causing pain and restricted movement. The best known are ankylosing spondylitis and psoriatic arthritis where inflammation of the spine and joints is common and all the bones in the spine may eventually fuse together. These diseases attack the sites where tendons and ligaments insert into bone, but the cause of these chronic disabling conditions is poorly understood. There is preliminary evidence that joint inflammation could be caused by microscopic tissue injury as a result of mechanical stress at and near the sites where tendons and ligaments insert into bone. This project will further explore why inflammation happens at these sites. If microscopic damage is proven it will increase our understanding and may indicate new treatments for these common and distressing conditions.