Limb lengthening and muscle repair
This research was completed on 31 December 2002
|Project Leader||Dr Pamela E Williams, Professor Geoffrey Goldspink and Dr Alasdair H R W Simpson, DM, FRCS|
|Location||Department of Biological Sciences, University of Hull in conjunction with Anatomy and Developmental Biology, Royal Free and University College Medical School, London and the Musculoskeletal Research Unit, University of Edinburgh.|
|Grant awarded||30 November 1999|
|Start date||1 January 2001|
|End date||31 December 2002|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.The surgical lengthening of a bone to correct discrepancy of limb-length often results in damage to the soft tissues such as muscle, and in some cases this damage appears to be permanent, leading to a reduced range of movement and muscle weakness. Usually, muscle fibre damage is followed by a process of regeneration, during which proteins are produced which may effectively be used as ³markers² indicating that such repair is occurring. These researchers aim to determine whether the presence of these markers can also be used as an indicator of successful adaptation to limb-lengthening i.e. with good patient outcome and, conversely, whether their absence is linked with poor outcome. Should this be the case, this test could then be used to monitor progress after corrective surgery and, if necessary, to adjust the limb lengthening procedure to maximise patient recovery.