MRSA and C difficile infections: developing new antibiotics from maggot secretions | Children's Charity

MRSA and C difficile infections: developing new antibiotics from maggot secretions

This research was completed on 7 February 2013

Project LeaderDr E Dudley
Project team
  • Dr Y Nigam (joint PI)
  • Professor P Dyson
  • Dr R Del Sol Abascal
LocationCollege of Medicine and College of Human and Health Sciences, Swansea University
Duration4 months
Grant awarded21 September 2012
Provisional start date8 October 2012
Provisional end date7 February 2013
Grant amount£10,000.00
Grant codeGN2108

We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.

Work previously funded by Action Medical Research has allowed for the identification of a novel antibiotic found in the secretions of the maggot, Lucilia sericata, which is used in medicine to cleanse wounds. The antibiotic has been shown to be active against a wide range of bacteria responsible for infections such as MRSA and Clostridium difficile and the research led to identification of the structure of the new antibiotic.

This new project will investigate the antibacterial activity of this compound and slightly altered forms of the structure to determine which parts of the molecule are essential for antibiotic activity. Furthermore, the team will study at what concentrations the antibiotic is effective and whether it kills bacteria or just prevents their further growth. In the future, it is hoped that new antibiotics will be developed that are based on this natural compound to help prevent serious infections, such as MRSA, that are becoming more resistant to treatment with standard antibiotics.

Help us spread the word