MRSA and C difficile infections: developing new antibiotics from maggot secretions
This research was completed on 7 February 2013
|Project Leader||Dr E Dudley|
|Location||College of Medicine and College of Human and Health Sciences, Swansea University|
|Grant awarded||21 September 2012|
|Provisional start date||8 October 2012|
|Provisional end date||7 February 2013|
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Work previously funded by Action Medical Research has allowed for the identification of a novel antibiotic found in the secretions of the maggot, Lucilia sericata, which is used in medicine to cleanse wounds. The antibiotic has been shown to be active against a wide range of bacteria responsible for infections such as MRSA and Clostridium difficile and the research led to identification of the structure of the new antibiotic.
This new project will investigate the antibacterial activity of this compound and slightly altered forms of the structure to determine which parts of the molecule are essential for antibiotic activity. Furthermore, the team will study at what concentrations the antibiotic is effective and whether it kills bacteria or just prevents their further growth. In the future, it is hoped that new antibiotics will be developed that are based on this natural compound to help prevent serious infections, such as MRSA, that are becoming more resistant to treatment with standard antibiotics.