Parkinson's and MSA - Accurate Diagnostics | Action Medical Research | Children's Charity

Parkinson’s and MSA – development of an accurate diagnostic test

This research was completed on 30 September 2005

Project LeaderProfessor P D Griffiths FRCR, PhD, Professor M N J Paley PhD, FInstP and Dr R A Grünewald MA, DPhil, FRCP.
LocationAcademic Department of Radiology, Royal Hallamshire Hospital, Sheffield in conjunction with the Section of Neurology, Royal Hallamshire Hospital, Sheffield.
Grant awarded12 March 2001
Start date1 October 2003
End date30 September 2005
Grant amount£66,373.00
Grant codeAP0878

We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.

Parkinson’s disease (PD) is characterised by movement disorders where patients become progressively slow, stiff and shaky. It affects 1 in every 100 of people over the age of 65 years and the cause is unknown. There is no accurate diagnostic test for PD and the clinical diagnostic criteria can result in almost 1 in 5 patients being wrongly diagnosed with PD when they have another condition with similar symptoms such as multiple system atrophy (MSA). Iron is essential for a number of brain processes but increased levels may be damaging, resulting in neurodegeneration. This team will employ brain scanning to determine whether brain iron content can be used as a measure of PD progression. The aim is to develop a diagnostic technique to distinguish PD from MSA before this is possible in the clinic and also to improve our understanding of the disease process.

Help us spread the word