Pre-eclampsia - the role of oxygen
This research was completed on 31 January 2005
|Project Leader||Professor C W G Redman, MA, FRCP, FRCOG, Dr I L Sargent, BSc, PhD and Dr E A Linton, BSc, PhD.|
|Location||Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford.|
|Grant awarded||12 July 2001|
|Start date||1 February 2002|
|End date||31 January 2005|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.Pre-eclampsia is a common complication of pregnancy. There is currently no effective treatment and in severe cases, doctors have no choice but to deliver the baby early. 1 in every 10 pregnant women is at least mildly affected and for 1 in every 25 it causes serious complications. Every year between 500 – 600 babies and up to 10 mothers die as a result of pre-eclampsia. The cause of this devastating condition is currently unknown. These researchers are developing evidence from their previous studies (including one supported by Action Medical Research) that shedding of tissue debris from the placenta into the mother’s circulation could lead to pre-eclampsia. They will investigate whether a shortage of oxygen in the placenta causes increased debris and how protective anti-oxidants (including vitamins C and E) could prevent or ameliorate this process. The aim is to help treat pre-eclampsia which would also reduce the number of pre-term births.