Pre-eclampsia - the role of oxygen | Children's Charity

Pre-eclampsia - the role of oxygen

This research was completed on 31 January 2005

Project LeaderProfessor C W G Redman, MA, FRCP, FRCOG, Dr I L Sargent, BSc, PhD and Dr E A Linton, BSc, PhD.
LocationNuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford.
Grant awarded12 July 2001
Start date1 February 2002
End date31 January 2005
Grant amount£139,471.00
Grant codeSP3732

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Pre-eclampsia is a common complication of pregnancy. There is currently no effective treatment and in severe cases, doctors have no choice but to deliver the baby early. 1 in every 10 pregnant women is at least mildly affected and for 1 in every 25 it causes serious complications. Every year between 500 – 600 babies and up to 10 mothers die as a result of pre-eclampsia. The cause of this devastating condition is currently unknown. These researchers are developing evidence from their previous studies (including one supported by Action Medical Research) that shedding of tissue debris from the placenta into the mother’s circulation could lead to pre-eclampsia. They will investigate whether a shortage of oxygen in the placenta causes increased debris and how protective anti-oxidants (including vitamins C and E) could prevent or ameliorate this process. The aim is to help treat pre-eclampsia which would also reduce the number of pre-term births.
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