This research was completed on 7 May 2005
|Project Leader||Dr F Lyall, BSc, PhD, Professor S C Robson, MBBS, MRCOG, MD and Dr J N Bulmer, MB ChB, PhD, MRCPath.|
|Location||Institute of Medical Genetics, Glasgow in conjunction with the Department of Obstetrics and Gynaecology and the Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne.|
|Grant awarded||22 October 1999|
|Start date||15 November 2000|
|End date||7 May 2005|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.
These researchers are studying three problems of pregnancy (pre-eclampsia, fetal growth restriction and early pregnancy failure) which may have similar causes. The conditions can have serious consequences for the well-being of the baby and also for the mother. Babies who survive are at increased risk of disorders such as cardiovascular disease and diabetes in adult life. In normal pregnancies, cells known as trophoblasts invade and modify the blood vessels in the mother's womb, ensuring an increased supply of oxygen and nutrients to the baby. This team is investigating why, in abnormal pregnancies, this process fails. They will be studying substances normally released by the trophoblast cells to see if they are failing to function properly in abnormal pregnancies.