Seizures in Babies: Improving Diagnosis | Action Medical Research | Children's Charity

Seizures in babies: could a new imaging technique improve diagnosis?

This research was completed on 30 September 2014

Over 2,000 newborn babies born at full term suffer seizures each year in the UK.1 Early diagnosis and treatment are vital, as seizures may cause lasting brain damage. However, seizures sometimes go unnoticed, as babies can have no obvious symptoms. Dr Topun Austin, of The Rosie Hospital, Cambridge, is investigating whether a cutting-edge new technique – which combines imaging the brain with monitoring of its electrical activity – might improve diagnosis and allow more babies to benefit from early treatment.

What is the problem and who does it affect?

Around two or three babies in every 1,000 born alive suffer from seizures within a month of birth.2,3 Babies born very prematurely are especially vulnerable to seizures, as are babies who suffer from a lack of oxygen during birth.

‘Seizures remain a major challenge when caring for newborn babies,’ explains Dr Austin. ‘They result from abnormal bursts of electrical activity in the brain, but can be difficult to diagnose, as babies do not necessarily have any obvious symptoms. Abnormal movements may be subtle or not even present.’

Babies who are suspected of suffering from seizures are normally referred for specialist tests. ‘The current diagnostic test is an electroencephalogram (EEG), which measures electrical activity within the brain,’ explains Dr Austin. ‘EEG has limitations though, as it can only detect seizures occurring near the surface of the brain. It cannot detect abnormalities deeper within the brain.’

‘Treatment of seizures in newborn babies also remains difficult,’ continues Dr Austin. ‘Although drugs may suppress abnormal movements, they don’t always stop abnormal brain activity.’

Evidence suggests that on-going seizure activity can damage the brain. Better diagnosis and treatment of seizures are urgently needed.

What is the project trying to achieve?

Dr Austin is developing a new way to diagnose seizures, which combines existing EEG technology with a new optical imaging system.

‘When babies have a seizure, there is a large amount of electrical activity in the brain, which we are measuring with EEG,’ explains Dr Austin. ‘The amount of oxygen in the brain also changes, which we are measuring with the new optical system. The optical system works by shining near-infrared light into the brain, which is harmless and non-invasive.’

Dr Austin hopes the new combined technique will boost understanding of what’s happening inside the brain during seizures and improve diagnosis. ‘The ultimate aim is to develop the new system for routine use at the cot-side,’ explains Dr Austin. ‘We believe this could lead to better treatment of vulnerable babies, which could boost their chances in life.’

The new technique could also help other people with seizures or epilepsy.

What are the researchers’ credentials?

Project LeaderDr Topun Austin BSc MBBS MRCP (Paeds) MRCPCH PhD
Project team
  • Professor J Hebden
  • Professor D Holder
  • Dr A Gibson
  • Dr A Mitchell
  • Dr A Parker
LocationNeonatal Unit, The Rosie Hospital, Cambridge University
Other locations
  • Department of Paediatric Neurology, Addenbrooke's Hosptial, Cambridge University Hospitals NHS Foundation Trust
  • Department of Medical Physics and Bioengineering, University College London
DurationTwo years
Grant awarded10 November 2011
Start date1 October 2012
End date30 September 2014
Grant amount£131,150.00
Grant codeGN1945

We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.

This project brings together a team of clinicians and scientists with a proven track record in developing new technologies to study the infant brain. Most of the work is being carried out in a new neonatal unit – one of the largest in the country – at the Rosie Maternity Hospital, Cambridge.

References

  1. Rennie JM, Hagmann CF, Robertson NJ. Neonatal cerebral investigation. (2008) Cambridge University Press.
  2. Panayiotopoulos CP. Chapter 5. Neonatal seizures and neonatal syndromes. The Epilepsies: Seizures, Syndromes and Management. Bladon Medical Publishing (Oxfordshire UK) 2005. http://www.ncbi.nlm.nih.gov/books/NBK2599/
  3. Davis AS et al. Seizures in extremely low birth weight infants are associated with adverse outcome. J Pediatr 2010; 157: 720-5.
Help us spread the word