Spasticity - a genetic study
This research was completed on 3 November 2003
|Project Leader||Dr P A Wilkinson|
|Location||University Department of Clinical Neurosciences, Royal Free and University College Medical School, London|
|Grant awarded||19 May 2000|
|Start date||4 September 2000|
|End date||3 November 2003|
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Hereditary spastic paraparesis is a genetic condition causing weakness and stiffness of the legs, affecting approximately 1 in 10,000 people. Dr Wilkinson aims to identify new genes and characterise mutations within known genes which cause a particular form of this condition. He will also study the effect of these genes on cell function. This work should help us to understand the mechanisms of nerve cell death in the spinal cord. It should also improve genetic counselling and testing and may lead to new spasticity treatments.