Spasticity - a Genetic Study | Action Medical Research | Children's Charity | Children's Charity

Spasticity - a genetic study

This research was completed on 3 November 2003

Project LeaderDr P A Wilkinson
LocationUniversity Department of Clinical Neurosciences, Royal Free and University College Medical School, London
Grant awarded19 May 2000
Start date4 September 2000
End date3 November 2003
Grant amount£136,818.00
Grant codeSF0890

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Hereditary spastic paraparesis is a genetic condition causing weakness and stiffness of the legs, affecting approximately 1 in 10,000 people. Dr Wilkinson aims to identify new genes and characterise mutations within known genes which cause a particular form of this condition. He will also study the effect of these genes on cell function. This work should help us to understand the mechanisms of nerve cell death in the spinal cord. It should also improve genetic counselling and testing and may lead to new spasticity treatments.

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