Spasticity – neurodegenerative conditions affecting the spinal cord
This research was completed on 30 June 2003
|Project Leader||Dr E A L Reid, MRCP.|
|Location||Department of Medical Genetics, Addenbrooke's Hospital, Cambridge.|
|Grant awarded||13 March 2001|
|Start date||1 July 2001|
|End date||30 June 2003|
We do not provide medical advice. If you would like more information about a condition or would like to talk to someone about your health, contact NHS Choices or speak to your GP. Please see our useful links page for some links to health information, organisations we are working with and other useful organisations. We hope you will find these useful. We are not responsible for the content of any of these sites.The hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative conditions that affect the spinal cord and are characterised by progressive weakness and spasticity of the lower limbs. Those affected experience progressive difficulty in walking, and may eventually require a wheelchair. Some patients with HSP suffer additional problems, including muscle wasting, seizures, mental retardation, abnormal movements and impaired vision. There are approximately 3 – 6,000 affected individuals in the UK and no treatment is currently available to prevent or slow disease progression. This project aims to identify the genes that can cause HSP and improve our understanding of the molecular factors that are responsible for maintaining the normal health of the spinal cord.