Spasticity – neurodegenerative conditions affecting the spinal cord | Children's Charity

Spasticity – neurodegenerative conditions affecting the spinal cord

This research was completed on 30 June 2003

Project LeaderDr E A L Reid, MRCP.
LocationDepartment of Medical Genetics, Addenbrooke's Hospital, Cambridge.
Grant awarded13 March 2001
Start date1 July 2001
End date30 June 2003
Grant amount£74,490.00
Grant codeSP3706

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The hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative conditions that affect the spinal cord and are characterised by progressive weakness and spasticity of the lower limbs. Those affected experience progressive difficulty in walking, and may eventually require a wheelchair. Some patients with HSP suffer additional problems, including muscle wasting, seizures, mental retardation, abnormal movements and impaired vision. There are approximately 3 – 6,000 affected individuals in the UK and no treatment is currently available to prevent or slow disease progression. This project aims to identify the genes that can cause HSP and improve our understanding of the molecular factors that are responsible for maintaining the normal health of the spinal cord.
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